Human DHS, recombinant (C-6His)

Recombinant Human Deoxyhypusine Synthase is produced by our E.coli expression system and the target gene encoding Met1-Asp369 is expressed with a 6His tag at the C-terminus. Protein function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. [The UniProt Consortium]