Human CDCP1 ATF (30-368) Protein

Recombinant Human CDCP1 ATF (30-368) Protein is expressed from HEK293 with His tag at the N-terminus.It contains Phe30-Arg368. Tumor metastasis depends on the dynamic regulation of cell adhesion through beta1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. Protein function: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. [The UniProt Consortium]