Human ASIC4-Strep full length protein-synthetic nanodisc

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]. Human ASIC4-Strep full length protein-synthetic nanodisc. Protein function: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. [The UniProt Consortium]