HDAC10 (human, recombinant)

Histone deacetylase 10 (HDAC10) is a zinc-dependent metalloenzyme and class IIb HDAC. It is composed of an N-terminal catalytic domain and a C-terminal leucine-rich domain. HDAC10 is ubiquitously expressed and shuttles between the cytoplasm and nucleus. It acts as a transcriptional corepressor and deacetylates histones and polyamines, such as N8-acetylspermidine. HDAC10 is involved in DNA damage repair, autophagy, and inflammation. Overexpression of HDAC10 promotes proliferation of lung cancer cells in vitro, and knockout of Hdac10 protects mice against allergic airway inflammation. SNPs in HDAC10 have been found in patients with schizophrenia. Cayman's HDAC10 (human, recombinant) protein has a calculated molecular weight of 67 kDa.Synonyms: Histone Deacetylase 10. Purity: >62% estimated by SDS-PAGE. Source: Recombinant human N-terminal DYKDDDDK-tagged HDAC10 expressed in insect cells. Amino Acids: 2-631. MW: 67 kDa. Formulation: (Request formulation change), 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 0.04% Tween-20, 20% glycerol, and 90 µg/ml DYKDDDDK peptide. UniProt Accession No: Q969S8.