Growth hormone receptor (GHR), partial, Macaca mulatta, recombinant

Organism: Macaca mulatta (Rhesus macaque). Source: E.coli. Expression Region: 19-264aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: FSGSEPTAAI LSRASWSLQS VNPGLKTNSS KEPKFTKCRS PERETFSCHW TDAVHHGSKS LGPIQLFYTR RNIQGQTQEW KECPDYVSAG ENSCYFNSSF TSVWIPYCIK LTSNGDTVDG KCFSVDEIVQ PDPPIALNWT LLNVSLTGIH ADILVRWEAP PNADIQKGWM VLEYELQYKE VNETKWKMMD PILSTSVPVY SLKVDKEYEV LVRSKRRNSR NYGEFSEVLY VTLPQMNQFT CEEDFY. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Reference: "Monkey growth hormone (GH) receptor gene expression. Evidence for two mechanisms for the generation of the GH binding protein." Martini J.-F., Pezet A., Guezennec C.Y., Edery M., Postel-Vinay M.-C., Kelly P.A. J. Biol. Chem. 272:18951-18958(1997). Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).