GMP Human IL-7

Recombinant GMP Human IL-7 is expressed from E.coli without tag.It contains Asp26-His177. Interleukin (IL)-7 is a non-redundant cytokine in T-cell development and function. It is required in early T-cell development as well as for T-cell homeostasis and is secreted by stromal cells in the thymic and bone marrow (BM) environment. IL-7 binds to its receptor which is composed of the two chains IL-7Ralpha (CD127), shared with the thymic stromal lymphopoietin (TSLP), and the common gamma chain (CD132) for IL-2, IL-15, IL-9 and IL-21. Whereas gammac is expressed by most hematopoietic cells, IL-7Ralpha is nearly exclusively expressed on lymphoid cells. After binding to its receptor, IL-7 signals through two different pathways: Jak-Stat (Janus kinase-Signal transducer and activator of transcription) and PI3K/Akt responsible for differentiation and survival, respectively. Protein function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. [The UniProt Consortium]