Glucose-6-phosphate isomerase (EC 5.3.1.9), Escherichia coli

Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase or phosphohexose isomerase, is a dimeric enzyme that catalyzes the reversible isomerization of Dglucose-6-phosphate and D-fructose-6-phosphate. GPI also catalyzes the anomerization of D-glucose-6-phosphate. This enzyme is responsible for the second step of glycolysis and is involved in glucogenesis. Besides functioning as an isomerase, GPI serves as a neuroleukin, autocrine motility factor, and a differentiation and maturation mediator. Thus, GPI is one protein with several unique functions. It is thought that each of these functions is controlled by a unique active site. This makes GPI a classic example of a moonlighting protein, a protein that has more than one independent function. The enzyme is provided in 3.2 M ammonium sulphate. Activity: 2440 U/ml Temperature and pH optimum/stability: The optimum pH and temperature are 7.5 and 40°C, respectively. Shipping Conditions: Room Temperature. Storage Conditions: 2 °C to 8 °C. Features: >95% pure (SDS-PAGE). GPI, PGI, PHI, b4025, Phosphohexose isomerase, Phosphoglucose isomerase, Glucose-6-phosphate isomerase