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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32012-50 | 50 µg | - |
6 - 10 business days* |
292.00€
|
|||
Cay32012-1 | 1 mg | - |
6 - 10 business days* |
3,207.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Galectin 9 is a beta-galactoside-binding protein encoded by the LGALS9 gene and a member of the... more
Product information "Galectin 9 Short Variant (human, recombinant)"
Galectin 9 is a beta-galactoside-binding protein encoded by the LGALS9 gene and a member of the galectin family. It contains two non-identical carbohydrate recognition domains (CRDs) joined by a peptide linker, the length of which depends on alternative splicing of the LGALS9 gene, which produces a short, medium, or long variant of the protein. The non-identical CRDs are responsible for binding to different types of saccharide ligands with the N-terminal CRD (NCRD) preferring more complex glycoconjugates. Galectin 9 is localized to the cytosol, nucleus, and extracellular matrix and is expressed primarily in immune-related tissues and cells. When expressed on immune or tumor cells, galectin 9 binds to glycosylated sites on the immunoregulatory protein TIM-3 and activates signaling that impairs immune synapse formation leading to T cell anergy or apoptosis. It also binds to the transmembrane glycoprotein CD44 on osteoblasts, leading to their proliferation, and it has a role in cell adhesion by preventing hyaluronic acid from binding to CD44. The short variant of galectin 9 acts as an eosinophil chemoattractant. It also activates CD4+ T cell populations and induces naïve T cells to acquire a central memory T cell (TCM) phenotype. Galectin 9 was originally identified as a tumor antigen in patients with Hodgkin's disease. It is expressed to a lower extent in tumor cells compared with non-tumor cells but is increased in leukemia and colon cancer cell lines. Increased expression of the short variant of galectin 9 inhibits or enhances adhesion in breast or colon cancer cell lines, respectively. The expression of the short variant of galectin 9 is increased by interferon gamma (IFN-gamma) in synovial fibroblasts isolated from patients with rheumatoid arthritis. Cayman's Galectin 9 Short Variant (human, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, comprised of galectin 9 (amino acids 2-323) fused to human IgG1 Fc at its N-terminus, consists of 554 amino acids and has a calculated molecular weight of 61.8 kDa.Synonyms: Gal-9S, HUAT, Human Urate Transporter, Lectin Galactoside-binding Soluble 9, LGALS9A. Purity: >90% estimated by SDS-PAGE. Endotoxin Testing: < 1.0 EU/µg, determined by the LAL endotoxin assay. Source: Recombinant N-terminal human IgG1 Fc-tagged galectin 9 expressed in HEK293 cells. Amino Acids: 2-323 (full length). MW: 61.8 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4.
Keywords: | Gal-9S, HUAT, Human Urate Transporter, Lectin Galactoside-binding Soluble 9, LGALS9A |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32012 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 61.8 kD |
Purity: | >90% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K10093 | Matching products |
UniProt ID : | O00182 | Matching products |
Gene ID | GeneID 3965 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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