Frizzled-5 (human):Fc (human) (rec.)

Frizzled-5 (human):Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-40B-0133-C050 50 µg -

3 - 9 business days*

264.00€
AG-40B-0133-3050 150 µg (3 x 50 ug) -

3 - 9 business days*

528.00€
 
3 x 50 µg. The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the... more
Product information "Frizzled-5 (human):Fc (human) (rec.)"
3 x 50 µg. The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1. Protein function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. [The UniProt Consortium]
Keywords: Fz-5, hFz5, FzE5, FZD5, C2orf31, Frizzled-5
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0133

Properties

Application: Wnt3a binding assays
Conjugate: No
Expressed in: Human cells
Origin: Human
MW: 50 kD
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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