Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay33735-100 | 100 µg | - |
6 - 10 business days* |
439.00€
|
|||
Cay33735-1 | 1 mg | - |
6 - 10 business days* |
2,852.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Fibroblast growth factor receptor 1 (FGFR1) is a growth factor receptor with roles in cell... more
Product information "FGFR1 Extracellular Domain (human, recombinant)"
Fibroblast growth factor receptor 1 (FGFR1) is a growth factor receptor with roles in cell migration, differentiation, and survival, as well as apoptosis, chemotaxis, and embryonic development. It is composed of an N-terminal extracellular domain, which contains three immunoglobulin-like (Ig-like) domains, including the FGF ligand-binding domain, an acidic box, and a CAM-homology domain, a transmembrane domain, and a C-terminal tyrosine kinase domain. FGFR1 is expressed throughout the pre-differentiated mesenchyme of the cranium, in midfacial mesenchyme, and the endochondral skull base during early embryonic development, and broadly expressed in epithelial, osteogenic, and chondrogenic cell lineages by 10 to 13 weeks gestation. Upon ligand binding, FGFR1 dimerizes, resulting in autophosphorylation of the tyrosine kinase domain and activation of various intracellular signaling pathways, including the ERK/MAPK pathway. Mutations in FGFR1 induce various craniofacial dysostosis syndromes, such as Crouzon, Pfeiffer, and Jackson-Weiss syndromes that feature basicranial and midfacial deformities. FGFR1 amplifications, translocations, and fusions are associated with lung cancer, 8p11 myeloproliferative syndrome, and glioblastoma multiforme, respectively. Cayman's FGFR1 Extracellular Domain (human, recombinant) can be used for enzyme activity assays. This protein consists of 275 amino acids, has a calculated molecular weight of 31 kDa, and a predicted N-terminus of Arg22 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 50-55 kDa due to glycosylation.Synonyms: Basic Fibroblast Growth Factor Receptor 1, bFGF-R-1, BFGFR, CD331, Fibroblast Growth Factor Receptor 1, FGFBR, FLT2, Fms-like Tyrosine Kinase 2. Purity: >98% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg determined by the LAL endotoxin assay. Source: Active recombinant C-terminal human His-tagged FGFR1 expressed in HEK293 cells. Amino Acids: 22-285. MW: 31 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: P11362.
Keywords: | FGFR1, BFGFR, BFGFR, FLT-2, N-sam, CD331, BFGFR, FLT-2, N-sam, CD331, FGFR-1, FGFR-1, bFGF-R-1, bFGF-R-1, Proto-oncogene c-Fgr, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, Fms-like tyrosine kinase 2, Fibroblast growth factor receptor 1, Fibroblast g |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33735 |
Properties
Application: | Bioassay, Cell culture, Active protein |
Conjugate: | No |
Purity: | >98% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K04362 | Matching products |
UniProt ID : | P11362 | Matching products |
Gene ID | GeneID 2260 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H315, H319, H335, H373 |
P Phrases: | P260, P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P314, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed