FERM, ARHGEF and pleckstrin domain-containing protein 2 (FARP2), partial, human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 44-324aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: LHLRVKLLDN TMEIFDIEPK CDGQVLLTQV WKRLNLVECD YFGMEFQNTQ SYWIWLEPMK PIIRQIRRPK NVVLRLAVKF FPPDPGQLQE EYTRYLFALQ LKRDLLEERL TCADTTAALL TSHLLQSEIG DYDETLDREH LKVNEYLPGQ QHCLEKILEF HQKHVGQTPA ESDFQVLEIA RKLEMYGIRF HMASDREGTK IQLAVSHMGV LVFQGTTKIN TFNWSKVRKL SFKRKRFLIK LHPEVHGPYQ DTLEFLLGSR DECKNFWKIC VEYHTFFRLL D. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: n/a. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. Reference: n/a. Function: nan