Fc (human):Dectin-2 (mouse) (rec.)

Fc (human):Dectin-2 (mouse) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-40B-0139-C050 50 µg -

3 - 9 business days*

Mouse dectin-2 (aa 45-209) is fused at the C-terminus to the Fc portion of human IgG1. <0.01EU/?g... more
Product information "Fc (human):Dectin-2 (mouse) (rec.)"
Mouse dectin-2 (aa 45-209) is fused at the C-terminus to the Fc portion of human IgG1. <0.01EU/?g purified protein (LAL test, Lonza). Protein function: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. [The UniProt Consortium] Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain.
Keywords: Clec4n, Clec6a, Dectin-2, DC-associated C-type lectin 2, C-type lectin superfamily member 10, C-type lectin domain family 6 member A, Dendritic cell-associated C-type lectin 2
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0139


Conjugate: No
Expressed in: Human cells
Origin: Mouse
MW: 58 kD
Format: Lyophilized

Database Information

UniProt ID : Q9JKF4 | Find alternatives
Gene ID GeneID 56620 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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