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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40B-0138-C050 | 50 µg | - |
3 - 9 business days* |
341.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mouse dectin-1 (aa 72-244) is fused at the C-terminus to the Fc portion of human IgG1. <0.01... more
Product information "Fc (human):Dectin-1 (mouse) (rec.)"
Mouse dectin-1 (aa 72-244) is fused at the C-terminus to the Fc portion of human IgG1. <0.01 EU/?g purified protein (LAL test, Lonza). Protein function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. [The UniProt Consortium] Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain.
Keywords: | Bgr, Clec7a, Dectin-1, Beta-glucan receptor, DC-associated C-type lectin 1, C-type lectin superfamily member 12, C-type lectin domain family 7 member A, Dendritic cell-associated C-type lectin 1 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40B-0138 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | mouse |
MW: | 56 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K10074 | Matching products |
UniProt ID : | Q6QLQ4 | Matching products |
Gene ID | GeneID 56644 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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