Fc (human):Dectin-1 (mouse) (rec.)

Fc (human):Dectin-1 (mouse) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-40B-0138-C050 50 µg -

3 - 9 business days*

330.00€
 
Mouse dectin-1 (aa 72-244) is fused at the C-terminus to the Fc portion of human IgG1. <0.01... more
Product information "Fc (human):Dectin-1 (mouse) (rec.)"
Mouse dectin-1 (aa 72-244) is fused at the C-terminus to the Fc portion of human IgG1. <0.01 EU/?g purified protein (LAL test, Lonza). Protein function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. [The UniProt Consortium] Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain.
Keywords: Bgr, Clec7a, Dectin-1, Beta-glucan receptor, DC-associated C-type lectin 1, C-type lectin superfamily member 12, C-type lectin domain family 7 member A, Dendritic cell-associated C-type lectin 1
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0138

Properties

Conjugate: No
Expressed in: Human cells
Origin: Mouse
MW: 56 kD
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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