Fc gamma RIIa/FCGR2A/CD32a Protein(C-6His) (recombinant human)

Protein Construction: Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A is produced by our Mammalian expression system and the target gene encoding Ala36-Ile218 is expressed with a 6His tag at the C-terminus. Sequence: Ala36-Ile218. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 29 kDa. Protein function: Receptors for the Fc region of IgG (Fc?R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human Fc?Rs are divided into three classes designated Fc?RI (CD64), Fc?RII (CD32), and Fc?RIII (CD16), which generate multiple isoforms, are recognized. The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. Fc?RI binds IgG with high affinity and functions during early immune responses, whereas Fc?RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human Fc?RII (A, B, and C) and one for mouse (Fc?RIIB), encoding type I transmembrane proteins with ITAM motifs (Fc?RII A and C) or ITIM motifs (Fc?RIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin ? Fc region receptor II-a (IgG Fc r Protein function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. [The UniProt Consortium]