Exbumin(R)

Product Description: Exbumin(R) is a recombinant human serum albumin that is manufactured using good manufacturing practices at an ISO9001:2015 certified facility in Kansas, USA. It is blood-free and has been used in hundreds of thousands of injections. It is one of the few excipients available to improve viral stability for vaccines and gene therapies. Exbumin is also used to maintain tissue viability during cryo-preservation or storage. And, Exbumin helps to stabilize cells and tissue used in cell therapy and regenerative medicine applications. Exbumin has been approved for use as an excipient in injectable therapeutics by regulatory agencies. Advantages: Regulatory support available. Manufactured in the United States, in a tertiary-level, animal component-free, ISO 9001:2015 certified facility. Raw materials, manufacturing equipment, and packaging is certified blood free and animal free. Manufacturing equipment has never been exposed to animal derived components. Manufacturing host is blood free and animal free. Includes sodium specification to control sodium content for final formulationProtein function: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). [The UniProt Consortium]