Ectodysplasin Receptor/EDAR Protein(C-Fc) (recombinant mouse)

Protein Construction: Recombinant Mouse Ectodysplasin Receptor is produced by our Mammalian expression system and the target gene encoding Glu27-Ile189 is expressed with a Fc tag at the C-terminus. Sequence: Glu27-Ile189. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 58-88 kDa. Protein function: Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF-a receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse downless gene and defective in human dominant and recessive forms of autosomal hypohidrotic ectodermal dysplasia (EDA) syndrome. The extracellular domain of EDAR contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the death domains found in other TNFRSF members. EDAR has been suggested to be an early and important promoter of placode development in all ectodermal organs, such as uch as hair follicles, teeth and sweat glands. EDA-A1, the A1 isoform of EDA, is the EDAR ligand. EDA and EDA are implicated in appendage development by the cloning of a gene underlying hypohidrotic ectodermal dysplasia (HED) in mouse and human. HED is characterized by agenesis or malformation of ectoderm-derived appendages, such as teeth, sweat glands and hai Protein function: Receptor for EDA isoform TAA, but not for EDA isoform TA-2. May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. [The UniProt Consortium]