DOCK8 Protein, Mouse, Recombinant (His)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-TMPH-02623-20ug	20 µg		-		7 - 10 business days*		321.00€
TGM-TMPH-02623-100ug	100 µg		-		7 - 10 business days*		658.00€

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Description: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase... more

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Product information "DOCK8 Protein, Mouse, Recombinant (His)"

Description: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.

Keywords:	Dedicator of cytokinesis protein 8, DOCK8
Supplier:	TargetMol
Supplier-Nr:	TMPH-02623

Properties

Conjugate:	No
MW:	21.2 kD

Database Information

KEGG ID :	K21852 \| Matching products
UniProt ID :	Q8C147 \| Matching products
Gene ID :	GeneID 76088 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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