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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ATA-APrEST83633.100 | 100 µl | - | - |
7 - 10 business days* |
264.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104',... more
Product information "DDI2 PrEST Antigen"
Protein function: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.
| Keywords: | Protein DDI1 homolog 2 |
| Supplier: | Atlas Antibodies |
| Supplier-Nr: | APrEST83633 |
Properties
| Application: | Control antigen |
| Conjugate: | No |
| Host: | E.coli |
| Species reactivity: | human |
Database Information
| KEGG ID : | K11885 | Matching products |
| UniProt ID : | Q5TDH0 | Matching products |
| Gene ID : | GeneID 84301 | Matching products |
Handling & Safety
| Storage: | -20°C (avoid repeat freezing and thawing cycles) |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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