Cynomolgus GDF15, recombinant (N-8His-Flag)

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Item number	Size	Datasheet	SDS	Delivery time	Price
NOV-C31U.1mg	1 mg	-	-	10 - 14 business days*	-
NOV-C31U.10ug	10 µg	-	-	10 - 14 business days*	-
NOV-C31U.50ug	50 µg	-	-	10 - 14 business days*	-
NOV-C31U.500ug	500 µg	-	-	10 - 14 business days*	-

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Recombinant Cynomolgus Growth/differentiation factor 15 is produced by our Mammalian expression... more

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Product information "Cynomolgus GDF15, recombinant (N-8His-Flag)"

Recombinant Cynomolgus Growth/differentiation factor 15 is produced by our Mammalian expression system and the target gene encoding Ala197-Val308 is expressed with a 8His, Flag tag at C-terminus. Protein function: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28846097). On hepatocytes, inhibits growth hormone signaling. [The UniProt Consortium]

Keywords:	MIC-1, GDF-15, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, Recombinant Cynomolgus GDF15 (N-8His-Flag)
Supplier:	Novoprotein
Supplier-Nr:	C31U