Cyclophilin C/PPIase C/PPIC Protein(N-Trx, 6His) (recombinant human)

Protein Construction: Recombinant Human Peptidyl-Prolyl cis-trans Isomerase C is produced by our E.coli expression system and the target gene encoding Lys31-Asp182 is expressed with a Trx, 6His tag at the N-terminus. Sequence: Lys31-Asp182. Fusion tag: N-Trx Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 34 kDa. Protein function: Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so that both isomers are populated under biologically relevant conditions. Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin, although larger proteins can also contain prolyl isomerase domains. Protein function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. [The UniProt Consortium]