COX-2 (human recombinant)

COX-2 (human recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay60122-5 5 kU -

3 - 10 business days*

844.00€
 
Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs),... more
Product information "COX-2 (human recombinant)"
Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid (Cay-90010) to PGH2 (Cay-17020). Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 µM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme.
Keywords: COX2, PTGS2, COX-2, PHS II, PGHS-2, EC=1.14.99.1, PGH synthase 2, Cyclooxygenase-2, Prostaglandin H2 synthase 2, Prostaglandin G/H synthase 2, Prostaglandin-endoperoxide synthase 2
Supplier: Cayman Chemical
Supplier-Nr: 60122-5

Properties

Application: Enzyme activity
Conjugate: No
Purity: >75% (estimated by SDS-PAGE)

Database Information

KEGG ID : K11987 | Find alternatives
UniProt ID : P35354 | Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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