Contactin-associated protein 1 (CNTNAP1), partial, human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 26-356aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: DEELVGPLYA RSLGASSYYS LLTAPRFARL HGISGWSPRI GDPNPWLQID LMKKHRIRAV ATQGSFNSWD WVTRYMLLYG DRVDSWTPFY QRGHNSTFFG NVNESAVVRH DLHFHFTARY IRIVPLAWNP RGKIGLRLGL YGCPYKADIL YFDGDDAISY RFPRGVSRSL WDVFAFSFKT EEKDGLLLHA EGAQGDYVTL ELEGAHLLLH MSLGSSPIQP RPGHTTVSAG GVLNDQHWHY VRVDRFGRDV NFTLDGYVQR FILNGDFERL NLDTEMFIGG LVGAARKNLA YRHNFRGCIE NVIFNRVNIA DLAVRRHSRI TFEGKVAFRC L. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Ses to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Ses to darcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Reference: Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.Peles E., Nativ M., Lustig M., Grumet M., Schilling J., Martinez R., Plowman G.D., Schlessinger J.EMBO J. 16:978-988(1997). Function: Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.