Cofilin 1 protein-HIS Epitope

Recombinant full-length human Cofilin 1 was expressed in E. coli cells using an N-Terminal his epitope. The purity was determined to be >95% by densitometry. Protein function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. [The UniProt Consortium]