Cellastim S(R)

Product Description: Cellastim S(R) is recombinant human serum albumin that is completely blood-free and has been optimized specifically to enhance the performance in animal-free cell culture media due to the favorable lipid profile and other engineered attributes of the molecule. Cellastim S is ideally suited for a variety of different stem, primary, and production cell types that include immune cells, VERO, Mesenchymal Stem Cells, HEK, and CHO. Each lot tested in cell culture systems to ensure consistent quality and performance. Advantages: Manufactured in the United States in a tertiary-level, animal component-free, ISO 9001:2015 certified facility. Raw materials, manufacturing equipment, and packaging is certified animal-free. Host manufacturing system is of non-animal and non-human source. Complete supply and manufacturing chain is owned and operated by InVitria. Supplied as a lyophilized powder. Protein function: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). [The UniProt Consortium]