CD58 hFc Chimera, Human

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
GSC-Z04218-100	100 µg		-		7 - 10 business days*		403.00€
GSC-Z04218-500	500 µg		-		7 - 10 business days*		1,344.00€

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Loss of CD58 is a common mechanism for tumor immune evasion in lymphoid malignancies. CD58 loss... more

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Product information "CD58 hFc Chimera, Human"

Loss of CD58 is a common mechanism for tumor immune evasion in lymphoid malignancies. CD58 loss is known to occur due to both genetic and non-genetic causes, therefore, we hypothesized that restoring CD58 expression in lymphoma cells may be an effective treatment approach. EZH2 is involved in the epigenetic silencing of CD58 in lymphoma cells as a mechanism for tumor immune escape, and EZH2 inhibitors are able to restore epigenetically suppressed CD58 expression.

Keywords:	CD58, Surface glycoprotein LFA-3, Lymphocyte function-associated antigen 3
Supplier:	GenScript
Supplier-Nr:	Z04218

Properties

Conjugate:	No
Species reactivity:	human
MW:	48.1 kD
Purity:	>95% (Bis-Tris PAGE)

Database Information

KEGG ID :	K06492 \| Matching products
UniProt ID :	P19256 \| Matching products
Gene ID :	GeneID 965 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: °C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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