CD244 [2B4] (human)-muIg Fusion Protein (Biotin)

Liquid. Protein. A soluble molecule consisting of murine CD8 alpha signal peptide residual amino acids and linker the mature extracellular domain of human CD244 (199aa) and murine IgG2a Fc+hinge regions. Source: CHO cells. Liquid. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% sodium azide. Purity: . CD244 (2B4, SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.