CD24 (human) full length protein-exo

Exosomes (EXO) are secreted membrane nanoparticles formed by fusion of multivesicular bodies (MVBs) with the plasma membrane. The size of exosomes is about 30-150nm. Exosomes can be purified from in vitro cultures of cells. Like VLPs, EXO also shows outstanding immunogenicity and have the membrane structure close to that of the native plasma membrane. Overexpressed membrane proteins (MPs) were inserted in the host cell membrane and secreted out as Exosomes which can be purified and used for a series of downstream studies. Unlike VLPs, the purified EXO has minimal cytotoxicity. However, not all MPs can be included in EXO and secreted into medium. Protein function: May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin- like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. [The UniProt Consortium]