CD20 Extracellular Domain (human, recombinant, aa 141-188)

CD20 is a non-glycosylated protein encoded by MS4A1 in humans. It is composed of four transmembrane domains, a single intracellular loop, and two extracellular loop domains with both the N and C-termini located in the cytosol. CD20 is a general B cell marker that is expressed from the late pre-B lymphocyte stage but is not expressed by pro-B lymphocytes and is lost in terminally differentiated plasma cells and plasmablasts. It forms supramolecular complexes with CD53, CD81, and CD82, as well as MHCII, CD40, B cell receptors, and C-terminal Src kinase-binding protein (CBP) to contribute to signal transduction. MS4A1 expression is variable in B cell malignancies, with the lowest expression found in patients with chronic lymphocytic leukemia (CLL) and the highest expression found in patients with diffuse large B cell lymphoma (DLBCL) or hairy cell lymphomas. MS4A1 expression is enriched on IFN-gamma-inducible T-box transcription factor-expressing B cells in blood isolated from patients with multiple sclerosis. Cayman's CD20 Extracellular Domain (human, recombinant, aa 141-188) protein consists of 218 amino acids and has a calculated molecular weight of 23. kDa. By SDS page, under reducing conditions, the apparent molecular mass of the protein is approximately 28 kDa.