CD123 [IL-3Ralpha] (human)-muIg Fusion Protein (preservative free)

Liquid. Protein. A soluble molecule consisting of the extracellular domain of mature human CD123 fused to murine IgG2a Fc. Source: CHO cells. Liquid. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl. Human CD123 (Interleukin-3 Receptor alpha) is a 70kDa type I transmembrane molecule, and is the low affinity receptor for the cytokine IL-3, which can stimulate proliferation or differentiation. When paired in a heterodimer with CD131 (IL-3Rbeta), it binds IL-3 with much higher affinity. CD123 is found on myeloid precusors, stem cells, a subset of T cells, some B cells, megakaryocytes, basophils, monocytes and epithelial cells. CD123 is present at high levels on many hematologic malignancies, and antibodies and CAR T cells against CD123 have been used successfully to combat acute myeloid leukemia (AML).