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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay43693-50 | 50 µg | - | - |
5 - 10 business days* |
456.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
2-242 (full length). Protein function: Non-apoptotic caspase involved in epidermal... more
Product information "Caspase-14 (human, recombinant)"
2-242 (full length). Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). [The UniProt Consortium]
| Keywords: | CASP14, EC=3.4.22.- |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43693 |
Properties
| Conjugate: | No |
| Host: | E.coli |
| Species reactivity: | human |
| Purity: | >98% (SDS-PAGE) |
| Format: | Lyophilized |
Database Information
| KEGG ID : | K04401 | Matching products |
| UniProt ID : | P31944 | Matching products |
| Gene ID : | GeneID 23581 | Matching products |
Handling & Safety
| Storage: | -80°C |
| Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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