Calcineurin A alpha Isoform (human, recombinant)

Calcineurin A is the catalytic subunit of calcineurin, a serine/threonine phosphatase with roles in T cell activation, cardiac function, learning and memory, apoptosis, and cell cycle regulation. Calcineurin A has three isoforms, alpha, beta, and gamma, which are encoded by PPP3CA, PPP3CB, and PPP3CC, respectively. Calcineurin A alpha is composed of an N-terminal catalytical domain, binding regions for the regulatory subunit calcineurin B (Cay-34631) and the binding partner calmodulin, and a C-terminal autoinhibitory domain. It is ubiquitously expressed and associates with calcineurin B and calmodulin in a calcium-dependent manner. Calcineurin A alpha has roles in kidney development and function, as well as Tau dephosphorylation, but is dispensable for T cell development. Calcineurin A alpha-null mice exhibit impaired kidney function, failure to thrive, and shortened lifespan. Brain calcineurin A alpha levels are inversely correlated with disease severity in patients with Alzheimer's disease. Cayman's Calcineurin A alpha Isoform (human, recombinant) protein can be used for binding assays. This protein consists of 538 amino acids and has a calculated molecular weight of 60.8 kDa.Synonyms: Calmodulin-dependent Calcineurin A Subunit alpha Isoform, CALNA1, CAM-PRP Catalytic Subunit, CCN1, CNA1, PPP2B, PPP3CA, Protein Phosphatase 2B, Serine/threonine-Protein Phosphatase 2B Catalytic Subunit alpha Isoform. Purity: >94% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg determined by the LAL endotoxin assay. Source: Active recombinant human N-terminal His-tagged calcineurin A expressed in insect cells. Amino Acids: 2-521 (full length). MW: 60.8 kDa. Formulation: (Request formulation change), Lyophilized from sterile 20 mM Tris, pH 8.0, with 500 mM sodium chloride and 10% glycerol. UniProt Accession #: Q08209.