Cadherin-11/OB-Cadherin/CDH11 Protein(C-Fc-6His) (recombinant human)

Protein Construction: Recombinant Human Cadherin-11 is produced by our Mammalian expression system and the target gene encoding Phe23-Thr617 is expressed with a Fc, 6His tag at the C-terminus. Sequence: Phe23-Thr617. Fusion tag: C-Fc-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 110 kDa. Protein function: Cadherin-11, also known as OSF-4, Osteoblast cadherin and CDH11, is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. It is shown that cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme. Protein function: Cadherins are calcium-dependent cell adhesion proteins. [The UniProt Consortium]