C10orf90 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-6547.20	20 µg	-	-	-	Request delivery time estimate		90.00€
ABS-PP-6547.100	100 µg	-	-	-	Request delivery time estimate		180.00€

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Protein function: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage.... more

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Product information "C10orf90 (human), recombinant protein"

Protein function: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys- 63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. May have a role in the assembly of primary cilia (Probable). [The UniProt Consortium]

Keywords:	(E2-independent) E3 ubiquitin-conjugating enzyme FATS, Centrosomal protein C10orf90, E2/E3 hybrid ubiquitin-protein ligase FATS, Fragile-site associated tumor suppressor homolog, FATS, Recombinant Human C10orf90 Protein
Supplier:	Absea
Supplier-Nr:	PP-6547

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	29.5 kD
Format:	Solution

Database Information

KEGG ID :	K16773 \| Matching products
UniProt ID :	Q96M02 \| Matching products
Gene ID :	GeneID 118611 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	-20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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