BRAP (human, recombinant)

Source: Active recombinant human BRAP expressed in E. coli . Amino acids: 2-592 (full length) . MW: 67.3 kDa. Protein Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport [The Uniprot Consortium]