Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein

Recombinant Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGA4.It contains Tyr34-Thr977(ITGA4) acidic tail and Glu20-His723(ITGB7) basic tail. Product Background: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. Product Tag: C-His-Avi. Activity: Immobilized Biotinylated Human ITGA4&ITGB7, His-Avi Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA. Amino Acid Range: Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail. Amino Acid Range: Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail. Endotoxin: Less than 1 EU per ug by the LAL method.