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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay14166-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
BRCA1-associated RING domain protein 1 (BARD1) is a binding partner of the breast and ovarian... more
Product information "BARD1 BRCT domains (human, recombinant)"
BRCA1-associated RING domain protein 1 (BARD1) is a binding partner of the breast and ovarian tumor suppressor (BRCA1). BARD1 binding to BRCA1 via the RING and BRCT domains regulates BRCA1 stability, cellular localization, and function. Heterodimeric BRCA1/BARD1 enhances BRCA1 functions, including the maintenance of genomic stability by participating in DNA repair mechanisms. Further, BRCA1/BARD1 heterodimers have been shown to have ubiquitin ligase activity. BARD1 has also been shown to mediate p53-dependent, BRCA1-independent apoptosis. BARD1 binding to the mRNA polyadenylation factor, cleavage stimulation factor-50, is involved in inhibiting mRNA processing and tumor suppression. BARD1 contains two BRCA1 C-terminal (BRCT) domains. BRCT domains are modular units of ~100 amino acids that fold independently and recognize linear phosphoserine or phosphothreonine regions to mediate protein-protein and protein-DNA interactions. BRCT domains were initially recognized in the C-terminal region of the breast cancer protein BRCA1, as well as the p53 binding protein and the yeast cell cycle checkpoint protein RAD9. BRCT domains often occur as tandem repeats at the C-terminal end of several proteins that are functionally diverse. Most BRCT domain-containing proteins participate in DNA-damage checkpoint control or DNA-repair pathways, or both. Thus, BRCT domain-containing proteins likely participate in the cellular response to DNA damage. This recombinant protein product contains the first and second BRCT domains of BARD1.Synonyms: BRCA1-Associated RING Domain Protein 1. Purity: >60%. Source: Recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 554-777. MW: 52.4 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol. UniProt Accession #: Q99728.
Keywords: | BARD1, BARD-1, BARD-1, BRCA1-associated RING domain protein 1, BRCA1-associated RING domain protein 1, RING-type E3 ubiquitin transferase BARD1, RING-type E3 ubiquitin transferase BARD1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14166 |
Properties
Application: | Binding assays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
Purity: | >60% |
Format: | Solution |
Database Information
KEGG ID : | K10683 | Matching products |
UniProt ID : | Q99728 | Matching products |
Gene ID | GeneID 580 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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