Atrial natriuretic peptide-converting enzyme (CORIN), partial, human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 428-801aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: CLYNPCLDSC GGSSLCDPNN SLNNCSQCEP ITLELCMNLP YNSTSYPNYF GHRTQKEASI SWESSLFPAL VQTNCYKYLM FFSCTILVPK CDVNTGEHIP PCRALCEHSK ERCESVLGIV GLQWPEDTDC SQFPEENSDN QTCLMPDEYV EECSPSHFKC RSGQCVLASR RCDGQADCDD DSDEENCGCK ERDLWECPSN KQCLKHTVIC DGFPDCPDYM DEKNCSFCQD DELECANHAC VSRDLWCDGE ADCSDSSDEW DCVTLSINVN SSSFLMVHRA ATEHHVCADG WQEILSQLAC KQMGLGEPSV TKLIQEQEKE PRWLTLHSNW ESLNGTTLHE LLVNGQSCES RSKISLLCTK QDCGRRPAAR MNKR. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: n/a. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. , [Isoform 2]: Has weaker endopeptidase activity compared to isoform 1. Reference: n/a. Function: nan