Amyloid-beta A4 Precursor Protein-Binding A3/APBA3/X11L2 Protein(C-6His) (recombinant human)

Protein Construction: Recombinant Human Amyloid beta A4 Precursor Protein-Binding Family A Member 3 is produced by our E.coli expression system and the target gene encoding Met1-Leu138 is expressed with a 6His tag at the C-terminus. Sequence: Met 1-Leu138. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 20 kDa. Protein function: Amyloid ß A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-a and -ß which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amyloid protein (APP) in vivo and may modulate processing of the ß-amyloid precursor protein (APP) and hence formation of ß-APP. Protein function: May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. [The UniProt Consortium]