Alpha-1 Antitrypsin

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay24560-100 100 µg -

6 - 10 business days*

205.00€
 
Alpha-1 antitrypsin is a serine protease inhibitor and member of the serpin superfamily. It has a... more
Product information "Alpha-1 Antitrypsin"
Alpha-1 antitrypsin is a serine protease inhibitor and member of the serpin superfamily. It has a five-stranded A beta-sheet and a mobile reactive center loop that acts as a pseudosubstrate for various proteases. Alpha-1 antitrypsin binds to a protease, undergoes proteolytic cleavage, and forms a covalent linkage between a carboxyl group in the reactive loop and the serine hydroxyl of the protease active site, effectively inactivating the enzyme which is then cleared from circulation. The primary targets of alpha-1 antitrypsin are neutrophil elastase and proteinase 3, however, it also inhibits trypsin, kallikreins 7 and 14, and matriptase. Alpha-1 antitrypsin protects the lower respiratory tract from proteolytic destruction via inhibition of neutrophil elastase and reduced serum levels of alpha-1 antitrypsin have been linked to early-onset liver disease and emphysema. Alpha-1 antitrypsin is an acute-phase protein that reduces production of inflammatory cytokines, inhibits apoptosis, blocks leukocyte degranulation and migration, as well as suppresses NF-kappaB nuclear translocation in monocytes. It delays disease onset in mouse models of inflammatory disease, including collagen-induced arthritis and experimental autoimmune encephalomyelitis (EAE).Synonyms: A1A, A1AT, AAT, alpha1-Antitrypsin. Purity: >90% estimated by SDS-PAGE. Source: Human plasma. MW: 54,000 kDa. Storage Buffer: Lyophilized in PBS, pH 7.4. UniProt Accession #: P01009.
Keywords: AAT, SPAAT, PRO0684, Serpin A1, Alpha-1-antitrypsin, Alpha-1-antiproteinase, Short peptide from AAT, Alpha-1 protease inhibitor
Supplier: Cayman Chemical
Supplier-Nr: 24560

Properties

Application: WB
Conjugate: No
Species reactivity: human
MW: 54 kD
Purity: >90% estimated by SDS-PAGE

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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