Alpha-1-antitrypsin 1-1/Serpin A1e (C-6His) (recombinant mouse)

Protein Construction: Recombinant Mouse Serpin A1e is produced by our Mammalian expression system and the target gene encoding Glu25-Lys413 is expressed with a 6His tag at the C-terminus. Sequence: Glu25-Lys413. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 47-60 kDa. Protein function: Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene. Protein function: Does not inhibit elastase or chymotrypsin. No target protease has been identified to date. [The UniProt Consortium]