A16 (strain G-10) VP4 Protein (Fc Tag) (recombinant cox)

Protein Construction: A DNA sequence encoding the VP4 of Coxsackievirus A16 (Cox A16) (strain G-10) (AAA50478.1) (Gly2-Lys69) was expressed with the Fc region of rabbit IgG at the C-terminus. Sequence: Gly2-Lys69. Fusion tag: C-rFc Endotoxin: < 1.0 EU per µg protein as determined by the LAL method. Protein function: Protein function: [Capsid protein VP1]: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target host cells. This attachment induces virion internalization. After binding to its receptor, the capsid undergoes conformational changes. Capsid protein VP1 N-terminus (that contains an amphipathic alpha- helix) and capsid protein VP4 are externalized. Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm. [The UniProt Consortium]