a-N-Acetylneuraminide a-2,8-Sialyltransferase/ST8SIA1 Protein(C-6His) (recombinant human)

Protein Construction: Recombinant Human alpha-N-Acetylneuraminide alpha-2,8-Sialyltransferase is produced by our Mammalian expression system and the target gene encoding Tyr49-Ser356 is expressed with a 6His tag at the C-terminus. Sequence: Tyr49-Ser356. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 48 kDa. Protein function: a-N-Acetylneuraminide a-2,8-Sialyltransferase (ST8SIA1) belongs to the glycosyltransferase 29 family. ST8SIA1 is a sialytransferase that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce GD3 and GT3. ST8SIA1 is highly expressed in melanoma cell lines, adult and fetal brain, low expressed in adult and fetal lung. ST8SIA1 may act as a type II transmembrane protein with a short N-termianl cytoplasmic domain and a single-pass transmembrane domain folowed by an enzymatic domain in the lument of the Golgi apparatus. Protein function: Involved in the production of gangliosides GD3 and GT3 from GM3, gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. [The UniProt Consortium]