14-3-3beta (human, recombinant)

14-3-3beta is a member of the 14-3-3 family of scaffolding proteins. It is composed of nine antiparallel alpha-helices, which contain one phosphopeptide binding site, and forms homodimers or heterodimers with other 14-3-3 isoforms to form a central channel with two ligand-binding grooves. 14-3-3beta is ubiquitously expressed with the highest levels found in the brain. It is involved in diverse biological processes, including PKC activity regulation, axon regeneration, and cytoskeleton stabilization in podocytes. Increased intratumoral levels of 14-3-3beta are associated with increasing tumor grade in patients with astrocytoma. Increased cerebrospinal fluid (CSF) levels of 14-3-3beta are associated with Alzheimer's disease. Cayman's 14-3-3beta (human, recombinant) protein consists of 248 amino acids, has a calculated molecular weight of 28 kDa, and two additional amino acids, Gly and Pro, at the N-terminus.