Mouse REG3G qPCR Primer Pair

Protein Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota , Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:22727489, PubMed:27830702, PubMed:36240758). Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury (PubMed:22727489). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:27830702). Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation (PubMed:28811323). Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents (PubMed:36240758). Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia (PubMed:35263589) , Has bacteriostatic activity , Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus [The Uniprot Consortium]