ZNRF1 (Vector pUC, Accession No. BC007235)

Length: 684 Sequence: atggggggca agcagagcac ggcggcccgc tcccggggcc ccttcccggg ggtctccacc gatgacagcg ccgtgccgcc gccgggaggg gcgccccatt tcgggcacta ccggacgggc ggcggggcca tggggctgcg cagccgctcg gtcagctcgg tggcaggcat gggcatggac cccagcacgg ccgggggggt gccctttggc ctctacaccc ccgcctcccg gggcaccggc gactccgaga gggcgcccgg cggcggaggg tctgcgtccg actccaccta tgcccatggc aatggttacc aggagacggg cggcggtcac catagagacg ggatgctgta cctgggctcc cgagcctcgc tggcggatgc tctacctctg cacatcgcac ccaggtggtt cagctcgcat agtggtttca agtgccccat ttgctccaag tctgtggctt ctgacgagat ggaaatgcac tttataatgt gtttgagcaa acctcgcctc tcctacaacg atgatgtgct gactaaagac gcgggtgagt gtgtgatctg cctggaggag ctgctgcagg gggacacgat agccaggctg ccctgcctgt gcatctatca caaaagctgc atagactcgt ggtttgaagt gaacagatct tgtccggaac accctgcgga Protein function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). [The UniProt Consortium]