ZNF451 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2799 Sequence: atgggagacc cggggtcgga gataatagaa tctgtccctc cagctggccc tgaggcatct gagtcaacaa cggatgaaaa tgaagacgac attcagtttg tcagtgaagg accattacga cctgttcttg aatacattga tctggtcagc agtgatgatg aagagcctag cacctcttat actgatgaga atattaaacg taaagaccat attgattatc agaaggataa agttgcttta actctggctc gtctagcccg ccatgttgaa gtggagaaac agcagaaaga agagaagaat agagcattca gagaaaaaat tgattttcag catgctcatg ggttacaaga attggaattt attcgaggac attctgatac agaagcagca agactgtgtg tggaccagtg gctaaaaatg ccaggactca aaacaggcac aattaattgt ggaacaaaaa gttcattccg aagaggaggc cacacgtggg tgtctgggaa accaatttta tgtcctataa tgcactgtaa caaggagttt gacaatgggc accttctctt aggacatttg aaaaggttcg atcactctcc atgtgatcca acaattacac tacatggacc tttcttcagc tcctttgctt gtgtagtatg ttataaaaaa tttgttactc aacaacaata tagagatcac ctttttgata aggaagccac agatgatgga cataacaaca accttcttcc tcagattatt cagtgttttg catgtccaaa ttgcttcctt ctttttagca gaaaggagga gtgttcaaag catatgtctg gaaagaatca tttccatcag agtttcaaac tgggtgataa caaaggaatt gcacatccaa tatctttccc atcttttgca aagaaacttt tgatctctct gtgcaaagat gttccctttc aagttaagtg tgtggcctgc cacaagacac tgcgttccca catggagctc actgcccatt tcagagttca ttgtcgaaat gctggacctg tagctgtagc tgagaagagc attacccagg ttgcagagaa attcatatta agaggttatt gtccagattg caatcaagtc tttgtggatg aaaccagcac ccaaaatcat aagcagaatt caggacacaa agtccgagtc attaactcag tggaagaatc agtcttactc tattgccaca gcagcgaagg gaacaaggat ccttcttctg acttgcattt attgttggat caatcaaaat tttcatcact taaaagaacc atgtctatta aagaatctag ctcactggag tgcattgcca ttccaaaaaa gaagatgaat ttaaaagata aaagccatga aggtgttgct tgtgtccaga aagaaaaatc agtagttaaa acctggttct gtgaatgcaa tcagcgattc ccaagtgaag atgcagtaga aaagcatgtt ttctcagcaa acacaatggg ttataaatgt gtggtctgtg gaaaggtatg tgatgattca ggggtcattc gtttacacat gagccggatt cacggagggg cacatttaaa taactttctt ttctggtgtc ggacatgcaa aaaggagtta acaaggaaag atactatcat ggcacatgtg actgaatttc ataatggaca cagatatttt tatgagatgg atgaggtaga aggtgaaact ttgccatcat cctctacaac attggataat ttgactgcta acaagccttc atcagctatt actgttattg atcattcccc ggcaaatagt tctccgaggg gtaaatggca atgccggatt tgtgaagata tgtttgattc ccaggaatat gtaaaacagc actgcatgtc tttggcaagc cacaagtttc atagatacag ctgtgctcac tgcagaaagc cttttcataa gatagaaaca ttgtaccgac attgccaaga tgagcatgac aatgagataa agattaaata cttctgtggg ctttgtgatc ttatctttaa tgtggaagaa gcatttctga gtcattatga ggagcaccac agcatagatt atgtatttgt gtcagaaaaa actgaaactt caattaaaac cgaagatgat tttccagtaa tagagaccag taaccagtta acttgtggtt gccgtgagag ttacatctgt aaagtcaaca gaaaagaaga ttatagcaga tgtctccaaa tcatgctgga taaaggaaaa ctgtggtttc gctgcagttt atgttcggca acagcacaga atttaaccga catgaacact catatccatc aagtgcacaa agaaaagagt gatgaggagg agcagcagta tgtaatcaag tgtggcacct gcaccaaagc atttcatgat cctgagagtg cacagcagca tttccataga aaacattgct tcttacagaa acccagtgtg gctcattttg gatctgaaaa atcaaacctg tacaagttta ctgctagtgc ctcacataca gagagaaaac tgaaacaggc aataaactat tcaaaaagtt tagacatgga gaaaggagtt gagaatgacc taagctatca gaatatagag gaagaaattg ttgagcttcc agatttggat tacctgcgaa ccatgactca tatagtcttt gtagattttg ataactggtc aaactttttt ggtcatctac cagggcatct aaaccaagga acatttattt ggggctttca aggtacggtt aataagaaaa acaaaagaaa actttttccc Protein function: E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). [The UniProt Consortium]