ZNF423 (Vector pUC, Accession No. BC112315)

Length: 3855 Sequence: ATGCATAAGA AGAGGGTTGA AGAGGGGGAG GCCTCAGACT TCTCGCTGGC CTGGGATTCC TCCGTGACAG CAGCAGGAGG CCTAGAAGGA GAGCCAGAGT GCGATCAGAA AACCAGCCGT GCGCTGGAAG ACAGGAACAG CGTGACAAGT CAAGAGGAGA GAAATGAGGA TGATGAAGAC ATGGAGGATG AATCAATTTA CACCTGCGAT CACTGTCAGC AGGACTTCGA GTCTCTGGCA GACCTGACGG ACCACCGGGC CCACCGCTGT CCTGGAGATG GTGATGACGA CCCACAACTC TCCTGGGTGG CCTCGTCTCC CTCCAGCAAG GATGTTGCGT CACCCACGCA GATGATCGGA GATGGTTGTG ACCTCGGCCT CGGCGAGGAG GAAGGGGGCA CGGGCCTGCC ATACCCTTGC CAGTTCTGCG ACAAGTCCTT CATCCGCTTG AGCTACTTGA AGAGGCACGA GCAGATCCAC AGCGACAAGC TGCCGTTCAA GTGCACCTAC TGCAGCCGCC TCTTCAAGCA CAAGAGGAGC CGCGACCGGC ACATCAAGCT GCATACGGGC GACAAGAAGT ATCACTGCCA CGAGTGCGAG GCAGCCTTCT CCCGCAGCGA CCACCTCAAG ATCCACCTGA AGACCCACAG CTCCAGCAAG CCCTTCAAGT GCACTGTGTG CAAGCGCGGC TTCTCCTCCA CCAGCTCGCT GCAGAGCCAC ATGCAGGCCC ACAAAAAGAA CAAGGAGCAT CTGGCCAAGT CGGAGAAGGA AGCCAAGAAG GACGACTTCA TGTGCGACTA CTGCGAGGAC ACCTTCAGCC AGACGGAGGA GCTGGAGAAG CACGTGCTCA CCCGCCACCC GCAGCTGTCC GAGAAGGCGG ACCTGCAGTG CATTCACTGC CCTGAGGTCT TCGTCGACGA GAACACACTG CTCGCCCATA TCCACCAAGC CCACGCCAAC CAGAAACACA AGTGCCCCAT GTGCCCTGAG CAGTTCTCCT CAGTGGAAGG TGTCTACTGC CACCTGGACA GCCACCGGCA GCCCGACTCC AGCAACCACA GTGTCAGTCC CGACCCTGTA CTGGGCAGCG TGGCCTCCAT GAGCAGCGCC ACACCCGACT CCAGCGCCTC TGTGGAGCGT GGCTCCACCC CGGACTCCAC CTTGAAGCCG CTGCGGGGGC AGAAGAAGAT GCGGGATGAC GGGCAGGGCT GGACCAAGGT GGTCTATAGC TGCCCCTATT GTTCCAAGCG GGACTTTAAC AGCCTGGCCG TGCTGGAGAT CCACCTGAAG ACCATCCACG CGGACAAGCC CCAGCAGAGC CACACATGTC AGATCTGCCT GGACTCCATG CCCACCCTCT ACAACCTCAA CGAGCACGTT CGCAAGCTGC ACAAGAACCA TGCCTACCCT GTGATGCAGT TTGGCAACAT CTCTGCCTTC CACTGCAACT ACTGCCCCGA GATGTTCGCC GACATCAATA GCCTGCAGGA GCACATCCGC GTCTCCCACT GCGGCCCCAA CGCCAACCCC TCTGACGGTA ATAATGCTTT CTTCTGCAAC CAGTGCTCCA TGGGTTTCCT TACTGAGTCC TCCCTCACCG AGCACATCCA GCAGGCCCAC TGCAGTGTGG GCAGTGCCAA ACTAGAGTCT CCGGTGGTGC AGCCCACGCA GTCCTTCATG GAGGTCTATT CCTGCCCCTA CTGCACCAAC TCCCCCATCT TTGGCTCCAT CCTGAAACTC ACCAAGCACA TCAAGGAGAA CCACAAGAAC ATTCCACTGG CCCACAGCAA GAAGTCCAAG GCCGAGCAGA GCCCAGTCTC GTCCGATGTG GAGGTGTCTT CCCCGAAGCG GCAGCGGCTC TCAGCAAGCG CCAACTCCAT CTCCAATGGG GAGTATCCTT GTAATCAATG CGACCTCAAG TTCTCCAACT TTGAGAGCTT CCAGACCCAC CTGAAGCTGC ACCTGGAGCT GCTGCTGCGG AAGCAAGCGT GCCCCCAGTG CAAAGAGGAC TTTGACTCCC AGGAGTCCCT CCTGCAGCAC CTGACAGTGC ATTACATGAC CACGTCGACC CACTATGTGT GCGAGAGCTG CGACAAGCAA TTTTCCTCGG TGGATGACCT GCAGAAGCAC CTGCTGGACA TGCACACCTT TGTGTTGTAC CACTGCACCC TGTGTCAGGA GGTCTTCGAC TCCAAGGTGT CCATCCAGGT GCACCTGGCG GTGAAGCACA GCAATGAGAA GAAGATGTAC CGCTGCACGG CCTGCAACTG GGACTTCCGC AAGGAGGCTG ACCTGCAGGT GCACGTCAAA CACAGCCACC TGGGCAACCC GGCCAAGGCT CACAAGTGCA TCTTCTGTGG GGAGACCTTC AGCACCGAGG TGGAGCTGCA GTGCCACATC ACCACACACA GCAAGAAGTA TAACTGTAAG TTCTGCAGCA AGGCCTTCCA CGCCATCATC CTGCTGGAGA AGCACCTGCG GGAGAAGCAC TGTGTGTTTG ATGCTGCGAC CGAGAACGGC ACGGCCAATG GGGTACCCCC AATGGCCACC AAGAAAGCTG AGCCTGCTGA CCTGCAGGGC ATGCTGCTTA AGAACCCTGA GGCACCTAAC AGCCATGAGG CCAGCGAGGA TGACGTGGAC GCGTCGGAGC CCATGTACGG CTGTGACATC TGCGGGGCGG CCTACACCAT GGAGGTGCTG CTGCAGAATC ACCGGCTGCG GGACCACAAT ATCCGGCCGG GCGAGGATGA TGGCTCACGC AAGAAGGCTG AGTTTATCAA GGGCAGTCAC AAGTGCAACG TTTGTTCACG GACTTTCTTC TCGGAGAACG GGCTACGGGA GCACCTGCAG ACGCACCGGG GCCCTGCCAA GCACTACATG TGTCCCATCT GTGGTGAGCG CTTCCCTTCG CTGCTGACGC TCACCGAACA CAAGGTGACC CACAGCAAGA GCCTGGACAC GGGCACCTGT CGCATCTGCA AGATGCCCCT GCAGAGCGAG GAGGAGTTTA TTGAGCACTG CCAGATGCAC CCTGACCTGC GCAACTCACT CACGGGCTTC CGCTGTGTGG TCTGCATGCA GACAGTCACT TCCACGCTTG AGCTCAAGAT CCATGGCACC TTCCACATGC AGAAGCTGGC GGGCAGCTCA GCGGCGTCCT CCCCCAATGG CCAGGGGCTG CAGAAGCTCT ACAAGTGCGC CCTGTGCCTC AAGGAGTTCC GCAGCAAGCA GGACCTGGTG AAGCTTGACG TCAATGGGCT GCCCTACGGC CTCTGCGCCG GCTGCATGGC CCGCAGCGCC AACGGACAGG TGGGTGGCCT GGCCCCGCCC GAGCCCGCCG ACCGGCCCTG TGCCGGCCTC CGTTGCCCCG AGTGCAGTGT CAAGTTTGAG AGTGCCGAAG ACCTGGAGAG CCACATGCAG GTGGACCACC GTGACCTCAC GCCGGAGACC AGTGGGCCCC GGAAAGGCAC CCAGACATCG CCAGTGCCCC GGAAAAAGAC ATACCAGTGC ATCAAGTGCC AGATGACCTT CGAGAACGAG AGAGAGATCC AAATCCACGT TGCCAACCAC ATGATTGAGG AAGGCATCAA CCACGAGTGT AAGCTGTGCA ACCAGATGTT CGACTCCCCG GCCAAGCTCC TCTGTCACCT CATTGAGCAC AGCTTCGAGG GCATGGGCGG CACCTTCAAA TGCCCCGTGT GTTTCACAGT CTTCGTCCAG GCCAACAAGT TGCAGCAGCA CATCTTTGCC GTGCACGGGC AGGAGGACAA GATCTACGAC TGCTCACAGT GCCCTCAGAA GTTCTTCTTC CAGACCGAGC TGCAGAACCA CACGATGAGC CAGCACGCAC Protein function: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation, this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. [The UniProt Consortium]