ZNF207 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1188 Sequence: atgggtcgca agaagaagaa gcagctgaag ccgtggtgct ggtattgtaa tagagatttt gatgatgaga agatccttat tcagcaccaa aaagcaaagc attttaaatg ccatatatgt cacaagaaat tgtatacagg actgccacca gtaccaggag caccaggaat gcctccaggc atacctccat taatgccagg tgttcctcct ctgatgccag gaatgccacc agttatgcca ggcatgccac ctggattgca tcatcagaga aaatacaccc agtcattttg cggtgaaaac ataatgatgc caatgggtgg aatgatgcca cctggaccag gaataccacc tctgatgcct ggaatgccac caggtatgcc cccacctgtt ccacgtcctg gaattcctcc aatgactcaa gcacaggctg tttcagcgcc aggtattctt aatagaccac ctgcaccaac agcaactgta cctgccccac agcctccagt tactaagcct cttttcccca gtgctggaca gatggggaca cctgtcacaa gctcaagtac agcttcatcc aattcagaaa gtctgtctgc atcttctaaa gctctgtttc ctagcacagc acaagctcag gcagctgtcc aaggacctgt tggtacagat ttcaaaccct taaatagtac ccctgcaaca actacagaac ccccaaagcc tacattccct gcttatacac agtctacagc ttcaacaact agtacaacaa atagtactgc agctaaacca gcggcttcaa taacaagtaa gcctgctaca cttacaacaa ctagtgcaac cagtaagttg atccatccag atgaggatat atccctggaa gagagaaggg cacagttacc taagtatcaa cgtaatcttc ctcggccagg acaggccccc atcggtaatc caccagttgg accaattgga ggtatgatgc caccacagcc aggcatccca cagcaacaag gaatgagacc cccaatgcca cctcatggtc agtatggtgg tcatcatcaa ggcatgccag gataccttcc tggtgctatg cccccgtatg ggcagggacc gccaatggtg cccccttacc agggtgggcc tcctcgacct ccgatgggaa tgagacctcc tgtaatgtcg caaggtggcc Protein function: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low- complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). [The UniProt Consortium]