ZKSCAN3 (Vector pENTR223.1, Accession No. BC006118)

Length: 1617 Sequence: atggctagag aattaagtga aagcacagcc ctggatgccc agtctacaga agaccagatg gagcttctgg tcataaaggt ggaggaagaa gaagccggtt ttcccagtag cccagatctg ggttctgagg gctcccgcga gcgcttccga ggcttccgct acccggaggc tgcaggcccc cgcgaggcgc tgagtcggct ccgagagctc tgccgacagt ggctgcagcc tgagatgcac agcaaggagc agatcctgga gctgctggtg ctggagcagt tcctgaccat cctgccgggg aatctgcaga gctgggtgcg ggagcagcat ccagagagcg gggaggaggt ggtggtgcta ttggagtatt tggagaggca gctggatgag ccggcgccgc aggtttcagg tgttgaccag gggcaagaac tgctctgttg caagatggca ctattgacac cagccccagg gtcacaaagt agccaatttc agctaatgaa ggctctgctc aagcatgaat ctgtgggatc ccagccttta caagatagag ttctccaggt ccccatgctt gcccatggag gatgctgcag agaagatgca gtggtagctt ctaggcttac tccagagtcc caggggttgt tgaaagtgga agatgtggcc ctgaccctca cccctgaatg gacacagcag gattcatctc aggggaatct ctgtagagat gaaaagcagg agaaccatgg cagcctggtc tccctgggtg atgaaaaaca gactaagagc agggacttgc ctccagctga ggagcttcca gaaaaggagc atgggaagat atcgtgccac ctgagagaag acattgccca gattcctaca tgtgcagaag ctggtgaaca ggagggcagg ctacaaagaa agcagaaaaa tgccacagga gggaggcggc acatctgcca tgaatgtgga aagagttttg ctcaaagctc aggcctgagt aaacacagga gaatccacac tggtgagaaa ccctacgaat gtgaagagtg tggcaaagcc ttcattggga gctctgccct tgtcattcat cagagagtcc acactggtga gaagccatat gagtgtgaag aatgtggtaa ggccttcagt catagctcag accttatcaa gcatcagaga acccacactg gggagaagcc ctatgagtgt gatgactgtg ggaagacctt cagccagagc tgcagcctcc ttgaacatca cagaatccac actggggaga agccgtatca gtgcagtatg tgtggcaaag cctttaggcg aagttcacat ctcctgagac atcagaggat ccatactggg gataaaaatg ttcaggaacc tgagcaggga gaggcctgga aaagtaggat ggaaagccag ttggaaaatg ttgaaactcc catgtcttat aaatgtaatg agtgtgaaag aagtttcact cagaatacag gcctcattga acatcaaaaa atccacactg gtgagaaacc ctatcagtgt aatgcgtgtg gaaaaggctt cacccgaatt tcataccttg ttcaacatca gagaagccat gtagggaaaa acatcctatc Protein function: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. [The UniProt Consortium]