ZDHHC15 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1014 Sequence: ATGCGGCGAG GCTGGAAGAT GGCTCTGTCT GGGGGGCTGC GGTGCTGCCG CCGGGTACTG TCCTGGGTGC CAGTGCTCGT TATTGTCCTC GTCGTGCTCT GGTCCTACTA TGCCTACGTC TTTGAACTCT GCCTGGTGAC TGTTTTGAGC CCAGCAGAAA AAGTTATTTA CCTCATACTC TACCATGCCA TCTTTGTGTT CTTTACCTGG ACCTACTGGA AGTCTATCTT TACACTCCCA CAGCAGCCAA ACCAGAAGTT CCACTTGTCC TACACAGACA AGGAGCGCTA TGAAAATGAA GAAAGACCTG AGGTCCAGAA GCAGATGCTT GTTGATATGG CCAAAAAGCT ACCGGTTTAC ACAAGAACTG GAAGTGGAGC TGTACGATTC TGTGACCGGT GTCATCTGAT CAAGCCAGAC CGCTGCCACC ACTGCTCTGT CTGTGCTATG TGTGTGTTAA AAATGGATCA TCACTGCCCT TGGGTTAATA ACTGCATTGG ATTTTCCAAC TACAAATTCT TCCTTCAATT CTTAGCTTAC TCTGTTCTCT ACTGCCTGTA CATTGCTACG ACAGTCTTCA GCTATTTCAT CAAATACTGG AGAGGGGAAT TACCCAGTGT TCGCTCTAAG TTCCATGTCC TTTTTCTTCT CTTTGTGGCC TGCATGTTTT TTGTCAGCCT TGTGATTCTC TTTGGTTACC ATTGTTGGCT TGTCAGCAGA AACAAAACCA CCTTAGAGGC CTTCTGCACT CCAGTGTTTA CAAGTGGCCC AGAGAAAAAT GGGTTCAACC TTGGCTTCAT CAAGAATATC CAGCAGGTGT TTGGAGATAA GAAGAAGTTC TGGTTAATAC CTATTGGTTC CAGCCCTGGT GATGGACACT CCTTCCCTAT GAGGTCTATG AATGAGTCAC AGAACCCACT GCTAGCAAAT GAAGAAACCT GGGAAGACAA CGAGGATGAC AACCAAGATT ATCCAGAAGG CTCATCATCT CTTGCTGTGG AAACGGAAAC Protein function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:18817523, PubMed:23034182). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed:18817523). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed:18817523). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis. Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon. Could also catalyze the palmitoylation of GAP43. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate FYN as shown in vitro (PubMed:19956733). [The UniProt Consortium]